{"id":2275,"date":"2020-05-05T02:31:47","date_gmt":"2020-05-04T23:31:47","guid":{"rendered":"http:\/\/www.ursak.org\/v3\/?page_id=2275"},"modified":"2020-05-06T10:57:57","modified_gmt":"2020-05-06T07:57:57","slug":"meme-kanseri","status":"publish","type":"page","link":"https:\/\/www.ursak.org\/v3\/bilgilendirme\/doktor-bilgilendirme\/meme-kanseri\/","title":{"rendered":"Meme Kanseri"},"content":{"rendered":"<p>Meme kanseri \u00fcreme ya\u015flar\u0131 kad\u0131nlarda en s\u0131k g\u00f6r\u00fclen malignite, her y\u0131l d\u00fcnya \u00e7ap\u0131nda yakla\u015f\u0131k 1,5 milyon kad\u0131n her sene meme kanserine yakalanmaktad\u0131r. Ne yaz\u0131k ki, meme kanseri ne yakalanan bir\u00e7ok gen\u00e7 kad\u0131n gonadotoksik kemoterapi rejimlerinin etkileri nedeniyle k\u0131s\u0131rl\u0131k ve premat\u00fcre yumurtal\u0131k yetmezli\u011fi (POF) ile kar\u015f\u0131 kar\u015f\u0131yad\u0131r. Siklofosfamid ve antrasiklinler gibi h\u00fccre-d\u00f6ng\u00fcs\u00fc spesifik olmayan ajanlar h\u00fccre d\u00f6ng\u00fcs\u00fcn\u00fcn her a\u015famas\u0131nda h\u00fccrelere zarar verir. 5-florourasil ve metotreksat gibi h\u00fccre d\u00f6ng\u00fcs\u00fcn\u00fcn S faz\u0131na \u00f6zg\u00fc bir \u015fekilde hareket eden kemoterapi ajanlar\u0131 primordial folik\u00fcller i\u00e7in daha az zararl\u0131d\u0131r ve preantral ve antral kohortlar gibi b\u00fcy\u00fcyen folik\u00fcllerin fraksiyonuna daha fazla zarar verme olas\u0131l\u0131\u011f\u0131 daha y\u00fcksektir. 40 ya\u015f\u0131n alt\u0131ndaki hastalar daha b\u00fcy\u00fck yumurtal\u0131k rezervine sahiptir ve kemoterapi ila\u00e7lar\u0131na maruz kald\u0131ktan sonra 40 ya\u015f\u0131ndan b\u00fcy\u00fck olanlara g\u00f6re adet fonksiyonlar\u0131n\u0131 koruma olas\u0131l\u0131\u011f\u0131 daha y\u00fcksektir. Siklofosfamid, metotreksat ve 5-florourasil (CMF) ve siklofosfamid, epirubicin ve 5-florourasil (CEF) gibi eski kemoterapi rejimlerinin iyi belgelenmi\u015f yumurtal\u0131k toksisitesi aksine, yeni takson i\u00e7eren protokoller i\u00e7in veri sadece son on y\u0131lda birikmi\u015ftir. Ayr\u0131ca Trastuzumab (anti HER2\/neu antikor), Lapatinib (anti HER2\/neu ve EGFR antikor) ve Fulvestrant (\u00f6strojen resept\u00f6r antagonisi) gibi hedefli tedavilerin yumurtal\u0131k fonksiyonu \u00fczerindeki etkisi hala bilinmemektedir. Meme kanserinin tedavisinde kullan\u0131lan kemoterapi ajanlar\u0131na ba\u011fl\u0131 amenore riski tabloda verilmi\u015ftir.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.ursak.org\/v3\/wp-content\/uploads\/2020\/05\/memekanseri-1.png\" alt=\"\" width=\"536\" height=\"462\" \/><\/p>\n<table style=\"height: 479px;\" width=\"\">\n<tbody>\n<tr>\n<td width=\"182\">\u00a0<\/td>\n<td width=\"110\"><strong>Kemoterapi s\u00fcresi (Ay)<\/strong><\/td>\n<td width=\"105\">\n<p><strong>Amenore riski<\/strong><\/p>\n<p><strong>&lt;40 ya\u015f<\/strong><\/p>\n<\/td>\n<td width=\"92\">\n<p><strong>Amenore riski<\/strong><\/p>\n<p><strong>&gt;40 ya\u015f<\/strong><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"182\"><strong>CMF <\/strong><\/td>\n<td width=\"110\">1-12<\/td>\n<td width=\"105\">4-74<\/td>\n<td width=\"92\">34-97<\/td>\n<\/tr>\n<tr>\n<td width=\"182\"><strong>FEC or CEF<\/strong><\/td>\n<td width=\"110\">6<\/td>\n<td width=\"105\">0-50<\/td>\n<td width=\"92\">49-92<\/td>\n<\/tr>\n<tr>\n<td width=\"182\"><strong>AC i\u00e7eren kombinasyonlar<\/strong><\/td>\n<td width=\"110\">4-6<\/td>\n<td width=\"105\">5.3-98<\/td>\n<td width=\"92\">44-96<\/td>\n<\/tr>\n<tr>\n<td width=\"182\"><strong>Taxane i\u00e7eren kombinasyonlar<\/strong><\/td>\n<td width=\"110\">4-8<\/td>\n<td width=\"105\">6-100<\/td>\n<td width=\"92\">17-100<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Meme kanseri \u00fcreme ya\u015flar\u0131 kad\u0131nlarda en s\u0131k g\u00f6r\u00fclen malignite, her y\u0131l d\u00fcnya \u00e7ap\u0131nda yakla\u015f\u0131k 1,5 milyon kad\u0131n her sene meme kanserine yakalanmaktad\u0131r. Ne yaz\u0131k ki, meme kanseri ne yakalanan bir\u00e7ok gen\u00e7 kad\u0131n gonadotoksik kemoterapi rejimlerinin etkileri nedeniyle k\u0131s\u0131rl\u0131k ve premat\u00fcre yumurtal\u0131k yetmezli\u011fi (POF) ile kar\u015f\u0131 kar\u015f\u0131yad\u0131r. Siklofosfamid ve antrasiklinler gibi h\u00fccre-d\u00f6ng\u00fcs\u00fc spesifik olmayan ajanlar h\u00fccre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":2174,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2275","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.ursak.org\/v3\/wp-json\/wp\/v2\/pages\/2275","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ursak.org\/v3\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ursak.org\/v3\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ursak.org\/v3\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ursak.org\/v3\/wp-json\/wp\/v2\/comments?post=2275"}],"version-history":[{"count":10,"href":"https:\/\/www.ursak.org\/v3\/wp-json\/wp\/v2\/pages\/2275\/revisions"}],"predecessor-version":[{"id":2512,"href":"https:\/\/www.ursak.org\/v3\/wp-json\/wp\/v2\/pages\/2275\/revisions\/2512"}],"up":[{"embeddable":true,"href":"https:\/\/www.ursak.org\/v3\/wp-json\/wp\/v2\/pages\/2174"}],"wp:attachment":[{"href":"https:\/\/www.ursak.org\/v3\/wp-json\/wp\/v2\/media?parent=2275"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}